alexa Point: Cancer Stem Cells—The Evidence Accumulates


Journal of Applied & Computational Mathematics

Author(s): Ebrahim Azizi

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The concept that cancers arise from “embryonic rests” and contain cell populations capable of self-renewal was proposed >100 years ago (1). Only within the past decade, however, has the accumulating research provided strong support for the cancer stem cell (CSC)2 hypothesis. This hypothesis posits that cancers arise in self-renewing cell populations and that the resulting cancers, like their normal organ counterparts, are composed of hierarchically organized cell populations. Self-renewing “cancer stem cells” maintain tumor growth and generate the diverse populations constituting the tumor bulk. The CSC hypothesis has tremendously important clinical implications.

This article was published in Clinical Chemistry and referenced in Journal of Applied & Computational Mathematics

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