alexa Polarographic behaviors of diclofenac sodium in the presence of dissolved oxygen and its analytical application.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Xu M, Chen L, Song J

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Abstract The polarographic response characteristics of diclofenac sodium were investigated in 0.25 M HAc-NaAc (pH 5.0) supporting electrolyte in the absence and the presence of dissolved oxygen. The results demonstrate that the reduction peak at ca. -1.10 V is a catalytic hydrogen wave after deaeration, and the reduction peak in the presence of dissolved oxygen is a so-called parallel catalytic hydrogen wave. Based on the parallel catalytic hydrogen wave, a novel method has been proposed for the determination of diclofenac sodium by single-sweep polarography. The calibration curve is linear in the range 1.2 x 10(-7)-2.6 x 10(-6)M and the detection limit is 6.0 x 10(-8)M. The proposed method is applied to the direct determination of diclofenac sodium in tablet forms and biological samples. This article was published in Anal Biochem and referenced in Pharmaceutica Analytica Acta

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