Author(s): Morey L, Helin K
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Abstract The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2. Copyright 2010 Elsevier Ltd. All rights reserved.
This article was published in Trends Biochem Sci
and referenced in Journal of Molecular Biomarkers & Diagnosis