alexa Polycomb silencers control cell fate, development and cancer.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Sparmann A, van Lohuizen M

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Abstract Polycomb group (PcG) proteins are epigenetic gene silencers that are implicated in neoplastic development. Their oncogenic function might be associated with their well-established role in the maintenance of embryonic and adult stem cells. In this review, we discuss new insights into the possible mechanisms by which PcGs regulate cellular identity, and speculate how these functions might be relevant during tumorigenesis. This article was published in Nat Rev Cancer and referenced in Journal of Clinical & Cellular Immunology

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