alexa Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment.
Medicine

Medicine

General Medicine: Open Access

Author(s): Christian R Halvorson, Matthew S Bremmer, Stephen C Jacobs

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Both autosomal dominant and recessive polycystic kidney disease are conditions with severe associated morbidity and mortality. Recent advances in the understanding of the genetic and molecular pathogenesis of both ADPKD and ARPKD have resulted in new, targeted thera - pies designed to disrupt cell signaling pathways responsible for the abnormal cell proliferation, dedifferentiation, apoptosis, and fluid secretion characteristic of the disease. Herein we review the current understanding of the pathophysiology of these conditions, as well as the current treatments derived from our understanding of the mechanisms of these diseases.

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This article was published in International Journal of Nephrology and Renovascular Disease and referenced in General Medicine: Open Access

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