alexa Polyp and adenoma detection rates in the proximal and distal colon.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Computer Science & Systems Biology

Author(s): Boroff ES, Gurudu SR, Hentz JG, Leighton JA, Ramirez FC

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Abstract OBJECTIVES: Little is known about the correlation between the polyp detection rate (PDR) and the adenoma detection rate (ADR) in individual colonic segments. The adenoma-to-polyp detection rate quotient (APDRQ) has been utilized in retrospective study as a constant to estimate ADR from PDR. It has been previously stated that diminutive polyps in the rectum are more likely to be non-adenomatous, compared with more proximal segments, yet the APDRQ uses data from the entire colon. We sought to characterize and compare ADR and PDR in each colonic segment, estimate ADR using the conversion factor, APDRQ, and assess the correlation between estimated and actual ADR for each colonic segment. METHODS: As part of a quality improvement program, a retrospective chart review was conducted of all outpatient colonoscopies performed by 20 gastroenterologists between 1 October 2010 and 31 March 2011 at a single academic tertiary-care referral center. PDR, ADR, and the APDRQ were calculated for each gastroenterologist, using data from the entire colon and then for each colonic segment separately. Actual ADR was compared with estimated ADR based on the measured APDRQ. RESULTS: During 1,921 colonoscopies, 2,285 polyps were removed; 1,122 (49\%) were adenomas. The mean (s.d.) PDR for the group was 49\% (12.4\%) (range, 16-64\%). The mean (s.d.) ADR was 31\% (7.4\%) (range, 13-42\%). PDR and ADR correlated well in segments proximal to the splenic flexure, but diverged in distal segments. ADR was significantly higher in the right colon (17.1\%) than in the left (13.5\%) (P=0.001). The correlation between estimated and actual ADR using the APDRQ was significantly higher in the right colon (r=0.95 (95\% confidence interval (CI), 0.87-0.98)) than in the left (r=0.59 (95\% CI, 0.17-0.83)) (P<0.05). CONCLUSIONS: Although PDR and ADR correlate well in segments proximal to the splenic flexure, they do not correlate well in the left colon. Caution should be exercised when using PDR as a surrogate for ADR if data from the rectum and sigmoid are included. This article was published in Am J Gastroenterol and referenced in Journal of Computer Science & Systems Biology

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