Author(s): Santangelo C, Var R, Scazzocchio B, Di Benedetto R, Filesi C,
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Abstract Excessive inflammation is considered as a critical factor in many human diseases, including cancer, obesity, type II diabetes, cardiovascular diseases, neurodegenerative diseases and aging. Compounds derived from botanic sources, such as phenolic compounds, have shown anti-inflammatory activity in vitro and in vivo. Recent data suggest that polyphenols can work as modifiers of signal transduction pathways to elicit their beneficial effects. These natural compounds express anti-inflammatory activity by modulation of pro-inflammatory gene expression such as cyclooxygenase, lipoxygenase, nitric oxide synthases and several pivotal cytokines, mainly by acting through nuclear factor-kappa B and mitogen-activated protein kinase signalling. This review will discuss recent data on the control of inflammatory signalling exerted by some dietary polyphenols contained in Mediterranean diet. A clear understanding of the molecular mechanisms of action of phenolic compounds is crucial in the valuation of these potent molecules as potential prophylactic and therapeutic agents.
This article was published in Ann Ist Super Sanita
and referenced in Journal of Nutrition & Food Sciences