alexa Polyvalent vaccines in fish: the interactive effects of multiple antigens.
Veterinary Sciences

Veterinary Sciences

Journal of Veterinary Science & Technology

Author(s): Busch RA

Abstract Share this page

Abstract Fermentation and cell-grown products commonly used as fish vaccines present a relatively crude mixture of antigenic and other immunologically active components to the immune system. The specific antigenic make-up and the potential protective immunogenicity of this mixture is dependent upon the strain of the pathogen, production parameters, inactivation methods, down-stream processing, product formulation, storage conditions and the delivery method under which the final product is applied. In the past ten years, commercial vaccine products for fish have more often consisted of mixtures of multiple products, including two, three, four and five vaccines. Such mixtures present an even more extensive and complex array of antigens to the immune system. Considering the fact that not all antigens stimulate a protective immune response, that antigens vary in their immuno-dominance relative to each other and that the immune system of fish has a defined and limited capacity to respond to individual antigenic substances, it becomes increasingly difficult to formulate these complex mixtures into safe and effective commercial products. The clonal capacity of fish to respond to multiple antigens may depend on a variety of factors including host species and age, water temperature, route of administration and temporal considerations. There is growing evidence that antigenic as well as non-antigenic components of vaccines can interact synergistically or antagonistically and that they can stimulate, cross-react with, inhibit or even suppress the immune response to specific antigens. This paper reviews current knowledge about the interactive effects of antigenic components of fish vaccines and gives specific examples of how these interactions might affect the formulation and performance of multivalent products. This paper also considers the potential basis for these interactive effects and discusses technical approaches that take advantage of this knowledge for the development of new multivalent products.
This article was published in Dev Biol Stand and referenced in Journal of Veterinary Science & Technology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 9th Global Veterinary Summit
    November 16-17, 2017 Las Vegas, USA
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords