Author(s): Brenner SE, Chothia C, Hubbard TJ
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Abstract Structural classifications aid the interpretation of proteins by describing degrees of structural and evolutionary relatedness. They have also recently revealed strikingly skewed distributions at all levels; for example, a small number of folds are far more common than others, and just a few superfamilies are known to have diverged widely. The classifications also provide an indication of the total number of superfamilies in nature.
This article was published in Curr Opin Struct Biol
and referenced in Journal of Glycomics & Lipidomics