Author(s): Kjaer SK, Breugelmans G, Munk C, Junge J, Watson M,
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Abstract Knowledge about the prevalence of human papillomavirus (HPV) on a population level is important. We conducted a large population-based study in Denmark to determine the overall and age-specific HPV prevalence, and HPV type distribution in women. Liquid-based cytology samples (SurePath) were collected consecutively. HPV testing was performed with Hybrid Capture 2 (HC2; Digene) (high-risk and low-risk probes), and LiPA (Innogenetics) was used for genotyping. We analyzed samples from 11,617 women; 94.0\% had normal cytology, 4.3\% atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion and 1.6\% had high-grade squamous intraepithelial lesion (HSIL). The HPV prevalence was 26.4\% with a peak in women 20-24 years (50.2\%) and then decreased without a second peak in older women. Among the youngest women (15-19 years), 14\% had HPV 16/18 and 16\% had HPV 6/11. Prevalence of high-risk HPV types increased from 19.2\% in women with normal cytology to 100\% in women with cervical intraepithelial neoplasia grade 3 (CIN3)/cervical cancer. HPV 16 was the most prevalent type (6.0\% of all women), and was also the most prevalent in women with HSIL (35.1\%) and CIN3 (53.2\%). Other common HPV types in women with CIN3 included HPV 52, 51, 31, 33 and 18. HPV 16/18 alone was present in 23\% of CIN3 lesions and 67\% of cervical cancers, and HPV 16/18 together with other high-risk HPV types was present in 41\% of CIN3 lesions. This suggests that an efficacious HPV 16/18 vaccine will have a substantial preventive potential in the general female population.
This article was published in Int J Cancer
and referenced in Chemotherapy: Open Access