alexa Porosity of β-tricalcium phosphate affects the results of lumbar posterolateral fusion.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Wang Z, Sakakibara T, Sudo A, Kasai Y

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Abstract STUDY DESIGN: Clinical case-control and cross-sectional study. OBJECTIVES: To determine the influence of different porosities of β-tricalcium phosphate (β-TCP) as a bone substitute combined with local autograft bone obtained from decompression for lumbar posterolateral fusion (PLF). SUMMARY OF BACKGROUND DATA: Several reports have documented a high bone fusion rate using β-TCP as a bone substitute. β-TCP is increasingly used to supplement autograft in lumbar PLF, but the influence of different porosities of β-TCP for the lumbar PLF has not been reported. METHODS: Sixty patients who were diagnosed with lumbar degenerative diseases and treated with 2-level noninstrumented lumbar PLF were divided into 2 groups. Thirty patients were treated with 75\% porous β-TCP (β-TCP-75 group), and the others were treated with 60\% porous β-TCP (β-TCP-60 group). The clinical and radiographic results of each patient were assessed at 2 years postoperatively. RESULTS: Both the groups showed a good improvement rate of the Japanese Orthopaedic Association score (JOA score) at 2 years postoperatively, but there were no significant differences between them. The β-TCP-75 group represented a bone fusion rate of 70.0\% (64.7\% in men, 76.9\% in women) and the β-TCP-60 group was 93.3\% (87.5\% in men, 100.0\% in women). The latter exhibited a significantly better bone fusion rate than the β-TCP-75 group (P<0.05). CONCLUSIONS: In lumbar PLF, 60\% porous β-TCP granules achieved a higher bone fusion rate than 75\% porous β-TCP granules. This article was published in J Spinal Disord Tech and referenced in Journal of Stem Cell Research & Therapy

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