alexa Post-cardiac injury syndrome and an increased humoral immune response against the major contractile proteins (actin and myosin).
Clinical Research

Clinical Research

Journal of Clinical Trials

Author(s): De Scheerder I, Vandekerckhove J, Robbrecht J, Algoed L, De Buyzere M, , De Scheerder I, Vandekerckhove J, Robbrecht J, Algoed L, De Buyzere M,

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Abstract To better understand the pathogenesis of the post-cardiac injury syndrome (PCIS) 2 models of cardiac injury were studied. One hundred twenty-nine patients who underwent cardiac surgery and 80 patients with acute myocardial infarction (AMI) were prospectively followed and the levels of anti-heart antibodies (AHA), anti-actin antibodies (AAA) and anti-myosin antibodies (AMA) were determined. In the surgical group, PCIS developed in 27 patients (21\%) and incomplete PCIS in 36 (28\%). In the AMI group, PCIS did not develop in any patient, but incomplete PCIS developed in 11 patients (14\%) (p less than 0.001). The surgical group showed a significantly higher humoral immune response than the AMI group when analyzed for AHA and anti-contractile protein antibodies. After cardiac surgery, AHA developed in 59 patients (46\%), AAA developed in 33 (26\%) and AMA developed in 49 (38\%); in the AMI group, significant levels of AHA, AAA and AMA developed in 16 (20\%), 7 (9\%) and 13 patients (16\%), respectively. These studies show a significant correlation between the PCIS clinical classification and auto-antibodies raised against heart contractile proteins.
This article was published in Am J Cardiol and referenced in Journal of Clinical Trials

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