alexa Postsynaptic receptor trafficking underlying a form of associative learning.
Psychiatry

Psychiatry

Journal of Depression and Anxiety

Author(s): Rumpel S, LeDoux J, Zador A, Malinow R

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Abstract To elucidate molecular, cellular, and circuit changes that occur in the brain during learning, we investigated the role of a glutamate receptor subtype in fear conditioning. In this form of learning, animals associate two stimuli, such as a tone and a shock. Here we report that fear conditioning drives AMPA-type glutamate receptors into the synapse of a large fraction of postsynaptic neurons in the lateral amygdala, a brain structure essential for this learning process. Furthermore, memory was reduced if AMPA receptor synaptic incorporation was blocked in as few as 10 to 20\% of lateral amygdala neurons. Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy. This article was published in Science and referenced in Journal of Depression and Anxiety

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