alexa Potential anti-inflammatory diterpenoids from the roots of Caesalpinia mimosoides Lamk.
Anesthesiology

Anesthesiology

Journal of Pain Management & Medicine

Author(s): Yodsaoue O, Karalai C, Ponglimanont C, Tewtrakul S, Chantrapromma S, Yodsaoue O, Karalai C, Ponglimanont C, Tewtrakul S, Chantrapromma S, Yodsaoue O, Karalai C, Ponglimanont C, Tewtrakul S, Chantrapromma S, Yodsaoue O, Karalai C, Ponglimanont C, Tewtrakul S, Chantrapromma S

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Abstract Anti-inflammatory assay-guided separation of extracts from the roots of Caesalpinia mimosoides Lamk. led to isolation of seven compounds: four diterpenes (1-4), a dimer (9), and two dibenzo[b,d]furans (10, 11) together with eleven known compounds. Their structures were elucidated by 1D- and 2D-NMR techniques as well as UV, IR, mass spectral data and comparison with literature values. The anti-inflammatory activities of all compounds were evaluated for inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Compounds 4, 6, 8, and 12-14 were also tested for the inhibitory effect on LPS-induced tumor necrosis factor-alpha (TNF-alpha) release in RAW264.7 cells. The results indicated that 4 possessed potent inhibitory activity for both tests with IC(50) values of 3.0 and 6.5 microM, respectively. Copyright © 2010 Elsevier Ltd. All rights reserved. This article was published in Phytochemistry and referenced in Journal of Pain Management & Medicine

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