alexa Potential of the test-negative design for measuring influenza vaccine effectiveness: a systematic review.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Sullivan SG, Feng S, Cowling BJ

Abstract Share this page

Abstract BACKGROUND: The test-negative design is a variant of the case-control study being increasingly used to study influenza vaccine effectiveness (VE). In these studies, patients with influenza-like illness are tested for influenza. Vaccine coverage is compared between those testing positive versus those testing negative to estimate VE. OBJECTIVES: We reviewed features in the design, analysis and reporting of 85 published test-negative studies. DATA SOURCES: Studies were identified from PubMed, reference lists and email updates. Study eligibility: All studies using the test-negative design reporting end-of-season estimates were included. STUDY APPRAISAL: Design features that may affect the validity and comparability of reported estimates were reviewed, including setting, study period, source population, case definition, exposure and outcome ascertainment and statistical model. RESULTS: There was considerable variation in the analytic approach, with 68 unique statistical models identified among the studies. CONCLUSION: Harmonization of analytic approaches may improve the potential for pooling VE estimates.
This article was published in Expert Rev Vaccines and referenced in Journal of Vaccines & Vaccination

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords