alexa Potentiation of antifungal activity of amphotericin B by essential oil from Cinnamomum cassia.
Microbiology

Microbiology

Journal of Bacteriology & Parasitology

Author(s): Giordani R, Regli P, Kaloustian J, Portugal H

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Abstract The antifungal activity of the essential oil from Cinnamomum cassia, alone or combined with amphotericin B, a drug widely used for most indications despite side-effects was investigated. The composition of the oil was analysed by GC/MS and characterized by its very high content of cinnamaldehyde (92.2\%). The minimal inhibitory concentration (MIC 80\%), used to evaluate the antifungal activity against Candida albicans, was determined by a macrobroth dilution method followed by a modelling of fungal growth. The essential oil of Cinnamomum cassia exhibited strong antifungal effect (MIC 80\% = 0.169 microL/mL and K(aff) = 18,544 microL/mL). A decrease of the MIC 80\% of amphotericin B was obtained when the culture medium contained essential oil concentrations ranging from 0.08 to 0.1 microL/mL. The strongest decrease (70\%) was obtained when the medium contained 0.1 microL/mL of essential oil. This potentiation of amphotericin B obtained in vitro may show promise for the development of less toxic and more effective therapies especially for the treatment of HIV infection. Copyright 2006 John Wiley & Sons, Ltd. This article was published in Phytother Res and referenced in Journal of Bacteriology & Parasitology

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