alexa Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics.
Engineering

Engineering

Journal of Biomimetics Biomaterials and Tissue Engineering

Author(s): Muschler GF, Midura RJ, Nakamoto C

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Abstract Stem cell activation and development is central to skeletal development, maintenance, and repair, as it is for all tissues. However, an integrated model of stem cell proliferation, differentiation, and transit between functional compartments has yet to evolve. In this paper, the authors review current concepts in stem cell biology and progenitor cell growth and differentiation kinetics in the context of bone formation. A cell-based modeling strategy is developed and offered as a tool for conceptual and quantitative exploration of the key kinetic variables and possible organizational hierarchies in bone tissue development and remodeling, as well as in tissue engineering strategies for bone repair.
This article was published in J Biomed Biotechnol and referenced in Journal of Biomimetics Biomaterials and Tissue Engineering

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