alexa Predicting age at menopause from serum antimüllerian hormone concentration.
Reproductive Medicine

Reproductive Medicine

Reproductive System & Sexual Disorders: Current Research

Author(s): Tehrani FR, Shakeri N, SolaymaniDodaran M, Azizi F

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Abstract OBJECTIVE: We aimed to estimate age at menopause using serum antimüllerian hormone (AMH) concentration. METHODS: We randomly selected 266 study participants from a pool of 1,265 eligible women in the Tehran Lipid and Glucose Study cohort. We measured AMH levels three times at about 3-year intervals. There were 63 occurrences of menopause in our participants over an average of 6-year follow-up. We built an accelerated failure time model using serum AMH level at the start of follow-up to estimate age at menopause. The goodness of fit for the model was tested using Cox-Snell residuals and the Bland-Altman plot. RESULTS: We estimated ages at menopause for different levels of serum AMH concentration among women aged 20 to 49 years. For those who reached menopause, serum AMH concentrations about 6 years before the event provided fairly accurate estimates of the age at menopause. The Bland-Altman plot showed an acceptable agreement between predicted and observed values. CONCLUSIONS: Serum AMH concentrations can reasonably forecast the age at menopause for individual women. This article was published in Menopause and referenced in Reproductive System & Sexual Disorders: Current Research

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