Author(s): Hmlinen MD, FrostellKarlsson A
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Abstract Today's pharma environment requires rapid and reliable methods of screening drug leads for intestinal permeability potential in the early stages of drug discovery. Techniques using excised tissues, Caco-2 cells, artificial membranes, 'in silico' techniques and surface plasmon resonance (SPR)-based biosensors are critically examined in terms of their reliability, measurement criteria, throughput and utility in identifying potentially successful or unsuccessful drug molecules.: © 2004 Elsevier Ltd . All rights reserved.
This article was published in Drug Discov Today Technol
and referenced in Journal of Bioequivalence & Bioavailability