alexa Prediction of type 1 diabetes.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Seidel D, Ziegler AG

Abstract Share this page

Abstract Prediction of type 1 diabetes is largely based on islet cell antibodies, but may be improved by combined analysis with other markers. We conducted a screening of first-degree relatives of type 1 diabetic patients in Germany using islet cell antibodies (ICA, indirect immunofluorescence on human pancreas) and insulin autoantibodies (IAA, radioimmunoassay) as screening markers. Of 1460 relatives tested, 2.3\% (n = 33) were identified to be ICA+ (> or = 10 JDFu) and 1.9\% (n = 27) to be IAA+ (> or = 50 nU/ml) in at least two subsequent serum samples. Of 44 antibody-positive relatives, 17 (39\%) progressed to clinical insulin-dependent diabetes mellitus (IDDM) within 5 years. Life-table analysis showed a 58\% risk of IDDM for ICA+ and 46\% risk for IAA+ individuals. ICA combined with IAA gave a risk of 67\% (p < 0.02 compared with ICA-, n.s. compared with IAA-). Of all relatives who progressed to clinical IDDM, only one was negative for ICA, but 6 were negative for IAA, resulting in a sensitivity of 94\% for ICA and 65\% for IAA. All antibody-positive relatives were characterized for HLA DR and DQ markers by genotyping. Relatives with 2 non DR3/ non-DR4 (DRx/x) alleles had no risk of IDDM, although they were consistently positive for one or more antibody specificities. We conclude that IAA screening is less sensitive than screening with ICA and relatives who lack ICA rarely progress to clinical disease. HLA analysis may be useful among antibody-positive relatives to define subgroups with a low risk of progression to exclude those from future intervention trials.
This article was published in Horm Res and referenced in Journal of Molecular Biomarkers & Diagnosis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 9th International Conference and Expo on Molecular & Cancer Biomarkers
    August 23-24, 2017 Birmingham, UK
  • 2nd International Conference on Medical Imaging and Diagnosis
    London, UK
  • 22nd International Conference on Cancer Drugs and Therapeutics
    Paris, France
  • International Conference on Oncology Nursing and Cancer Care
    Singapore City, Singapore
  • World Summit on Cell Signalling and Cancer Therapy
    Toronto, Canada
  • International Conference on Radiology and Imaging
    New York, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version