alexa Predictive value of renal resistive index in percutaneous renal interventions for atherosclerotic renal artery stenosis.
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): Yuksel UC, Anabtawi AG, Cam A, Poddar K, Agarwal S

Abstract Share this page

BACKGROUND: The clinical benefit of percutaneous interventional therapies for atherosclerotic renal artery stenosis (ARAS) is still obscure. Randomized trials conducted on general patient populations provided unsatisfactory results in justifying the interventional treatment. In this study, the predictive value of renal resistive index (RRI) was retrospectively analyzed in identifying the patients who may benefit from renal angioplasty and stenting. METHODS: The records of patients who underwent percutaneous intervention for ARAS were analyzed between 2006 and 2010; we compared the clinical outcomes with preprocedural RRI values. Seventy-three patients were included in the analysis. RRI is calculated as follows: RRI = 1 - (Vmin/Vmax). Patients with RRI ≤ 0.75 were grouped as low RRI (group I) and compared with high RRI patients (RRI >0.75, group II).The comparison was in follow-up systolic and diastolic blood pressures, blood creatinine levels, estimated glomerular filtration rate (eGFR) and need for anti-hypertensive therapy. Data were collected by a customized online database created using Research Electronic Data Capture (REDCap) application. RESULTS: The mean follow-up was 12.4 (9-14) months and 11.1 (5-14) months for groups I and II, respectively (P=NS). After follow-up, group I patients significantly improved compared to baseline in their blood creatinine levels (2.0 ± 1.2 mg/dL vs 1.5 ± 0.60 mg/dL; P<.05), eGFR (45.2 ± 26.2 mL/min vs 51.6 ± 23.8 mL/min; P<.05), systolic blood pressure (143.6 ± 31.0 mm Hg vs 129.6 ± 18.4 mm Hg; P<.05), diastolic blood pressure (73.6 ± 13.4 mm Hg vs 69.5 ± 9.5 mm Hg; P<.05), and need for anti-hypertensive drugs (2.2 ± 0.9 vs 2.0 ± 0.9; P<.05). However, in group II, follow-up blood creatinine levels (1.8 ± 0.7 mg/dL vs 2.1 ± 1.0 mg/dL; P<.05) increased and eGFR (39.99 ± 22.53 mL/min vs 36.3 ± 23.2 mL/min; P<.05) decreased, indicating continuing clinical deterioration despite the intervention. CONCLUSION: RRI ≤ 0.75 may predict better clinical outcomes after renal angioplasty and stenting. Preprocedural RRI can be considered a useful parameter in defining patients who may benefit from interventional procedures.

  • To read the full article Visit
  • Open Access
This article was published in J Invasive Cardiol and referenced in Journal of Clinical Research & Bioethics

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords