alexa Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome.
Gastroenterology

Gastroenterology

Journal of Gastrointestinal & Digestive System

Author(s): Wahnschaffe U, Schulzke JD, Zeitz M, Ullrich R

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Abstract BACKGROUND & AIMS: Gluten sensitivity might cause abdominal symptoms in the absence of villous atrophy. We examined the prevalence of celiac disease-associated serum antibodies in diarrhea-dominant irritable bowel syndrome (d-IBS) patients and their efficacy in combination with HLA-DQ2 expression to predict the response to gluten-free diet. METHODS: HLA-DQA1*0501/DQB1*0201 expression and celiac disease-associated IgA and IgG serum antibodies against gliadin and tissue-transglutaminase were measured in 145 patients with d-IBS, 74 patients with untreated and treated celiac disease, and 57 patients with active IBD. Follow-up antibody levels, stool frequency, and gastrointestinal symptom scores were determined in 41 d-IBS patients (26 women, 15 men; median age, 46 years, range, 30-67 years) who participated in a nonrandomized evaluation of 6 months of gluten-free diet. RESULTS: Increased celiac disease-associated serum IgG, but not IgA, was found in the majority of patients with treated (55\%) as in most patients with untreated celiac disease (97\%). In d-IBS patients, celiac disease-associated serum IgG antibodies (37\%) and HLA-DQ2 expression (39\%) were more frequent than in IBD patients (18\% and 23\%, respectively). After 6 months of gluten-free diet, stool frequency and gastrointestinal symptom score returned to normal values in 60\% of d-IBS patients who were positive and in 12\% who were negative for HLA-DQ2 and celiac disease-associated serum IgG; both parameters combined yielded positive and negative predictive values of 56\% (95\% confidence interval, 30\%-80\%) and 88\% (69\%-97\%), respectively. CONCLUSIONS: Celiac disease-associated serum IgG and HLA-DQ2 expression can identify likely responders to gluten-free diet in d-IBS patients. This article was published in Clin Gastroenterol Hepatol and referenced in Journal of Gastrointestinal & Digestive System

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