Author(s): Tanaka N, Yamada Y, Sakahashi H, Sato E, Ishii S, Tanaka N, Yamada Y, Sakahashi H, Sato E, Ishii S, Tanaka N, Yamada Y, Sakahashi H, Sato E, Ishii S, Tanaka N, Yamada Y, Sakahashi H, Sato E, Ishii S
Abstract Share this page
Abstract Abstract To determine the predictive factors for rheumatoid arthritis (RA), 79 patients (11 men, 68 women; average age at onset of symptoms 37.1 years) with fixed joint effusion of one knee joint, of minimum 6 months' duration, were divided into three groups: group I, 11 patients (14\%) who progressed to RA; group II, 8 patients (10\%) with the correct diagnosis, except that RA became apparent during the subsequent follow-up; group III, 60 patients (76\%) whose joint effusion resolved. In group I, the degree of joint effusion and the serological values of interleukin (IL)-1β, IgG-RF, and rheumatoid factor (RF) tended to be higher than those in the other groups at the time of our initial examination. The synovial fluid concentrations of IL-1β and IgG-RF in group I were significantly higher than those in the other groups. Magnetic resonance imaging (MRI)-determined stage and histological assessment of synovial inflammation also tended to be higher in group I than in the other groups. This study revealed that it might be possible to predict the outcome of cases of monoarthritis by examining IL-1β and IgG-RF levels in the synovial fluid, in addition to various elevated inflammation signs in the knee joint.
This article was published in Mod Rheumatol
and referenced in Journal of Arthritis