alexa Preoperative atrial fibrillation decreases event-free survival following cardiac surgery.


Journal of Clinical & Experimental Cardiology

Author(s): Kalavrouziotis D, Buth KJ, Vyas T, Ali IS

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Abstract OBJECTIVE: To investigate the relationship between preoperative atrial fibrillation and early and late clinical outcomes following cardiac surgery. METHODS: A retrospective cohort including all consecutive coronary artery bypass graft and/or valve surgery patients between 1995 and 2005 was identified (n = 9796). No patient had a concomitant surgical AF ablation. The association between preoperative atrial fibrillation and in-hospital outcomes was examined. We also determined late death and cardiovascular-related re-hospitalization by linking to administrative health databases. Median follow-up was 2.9 years (maximum 11 years). RESULTS: The prevalence of preoperative atrial fibrillation was 11.3\% (n = 1105), ranging from 7.2\% in isolated CABG to 30\% in valve surgery. In-hospital mortality, stroke, and renal failure were more common in atrial fibrillation patients (all p < 0.0001), although the association between atrial fibrillation and mortality was not statistically significant in multivariate logistic regression. Longitudinal analyses showed that preoperative atrial fibrillation was associated with decreased event-free survival (adjusted hazard ratio 1.55, 95\% confidence interval 1.42-1.70, p < 0.0001). CONCLUSIONS: Preoperative atrial fibrillation is associated with increased late mortality and recurrent cardiovascular events post-cardiac surgery. Effective management strategies for atrial fibrillation need to be explored and may provide an opportunity to improve the long-term outcomes of cardiac surgical patients. This article was published in Eur J Cardiothorac Surg and referenced in Journal of Clinical & Experimental Cardiology

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