alexa Preoperative chemotherapy-sensitized radiation therapy for cervical metastases in head and neck cancer.


Journal of Oncology Translational Research

Author(s): Puc MM, Chrzanowski FA Jr, Tran HS, Liu L, Glicksman AS,

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Abstract OBJECTIVE: To determine the efficacy of concurrent preoperative cisplatin chemotherapy and radiotherapy (CT/RT) for patients with advanced head and neck cancer and cervical metastatic disease. DESIGN: Retrospective analysis. SETTING: University hospitals. PATIENTS: Eighty-eight patients with operable stage III and IV squamous cell carcinoma of the head and neck and palpable cervical lymphogenous metastases received preoperative concurrent CT/RT followed by planned neck dissection. INTERVENTIONS: All patients undergoing CT/RT received concomitant continuous infusions of cisplatin (20 mg/m2) on days 1 to 4 and 22 to 25 of CT/RT. Thirty-nine patients underwent single-fraction (1.8-Gy) radiotherapy to 45.0 Gy, and 49 patients received 10 single-fraction (1.8-Gy) treatments, which were hyperfractionated (1.2-Gy twice a day) to 46.8 Gy. MAIN OUTCOME MEASURES: The 71 patients for whom complete post-CT/RT data were available were evaluated for clinical response in addition to survival. Histologic complete response (HCR) was confirmed from planned neck dissection specimens (n = 48) after clinical complete response (CCR) from initial CT/RT. Kaplan-Meier statistical analysis for disease-specific survival and overall survival was performed on all 88 patients who received CT/RT. RESULTS: A CCR and an HCR were noted in 78\% (18/23) and 59\% (10/17) of patients with N1 lesions, respectively, and in 60\% (29/48) and 45\% (14/31) of patients with N2-3 lesions, respectively. The percentage of patients with CCR who also had HCR was 67\% (10/15) for patients with N1 lesions and 54\% (14/26) for patients with N2-3 lesions. With a median follow-up of 18.5 months, the Kaplan-Meier disease-specific survival rate at 54 months (n = 88) was 70\% (21/30) for patients with N1 lesions, 60\% (24/40) for patients with N2 lesions, and 39\% (7/18) for patients with N3 lesions. The overall survival and disease-specific survival rates at 5 years for all nodal groups combined were 36\% (32/88) and 59\% (52/88), respectively. CONCLUSIONS: A CCR to CT/RT was achieved in nearly two thirds of patients with head and neck cervical lymphogenous metastases, independent of nodal tumor load. Most patients (59\% [24/41]) with CCR were pathologically tumor free before neck dissection.
This article was published in Arch Otolaryngol Head Neck Surg and referenced in Journal of Oncology Translational Research

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