alexa Presentation, treatment, and outcome of type 1 gastric carcinoid tumors.


Journal of Gastrointestinal & Digestive System

Author(s): Dakin GF, Warner RR, Pomp A, Salky B, Inabnet WB

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Abstract BACKGROUND AND OBJECTIVES: The aim of this study was to review the presentation, treatment, and outcome of patients with Type 1 gastric carcinoid tumors. METHODS: A retrospective review of 1,600 carcinoid patients was analyzed to identify patients with gastric carcinoid tumors. RESULTS: Eighteen patients were found to have biopsy-confirmed Type 1 gastric carcinoid tumors on upper endoscopy. Reasons for endoscopy included abdominal pain (n = 4), gastrointestinal bleeding (n = 4), surveillance for pernicious anemia (n = 8), and other (n = 2). The mean pre-treatment serum gastrin and chromogranin A levels were 1,436 ng/ml (+/-771 ng/ml) and 91.6 ng/ml (+/-68.6 ng/ml), respectively. Imaging revealed evidence of gastric carcinoid in 4 of 10 patients undergoing CT scanning and 3 of 10 patients undergoing octreotide scintigraphy. Of the 18 patients, 8 were treated medically (acidification or octreotide) and 10 were treated with surgery (laparoscopic antrectomy or partial gastrectomy). Mean gastrin levels decreased by 37.2\% in the medically treated group (median follow-up 6 months), versus 94.0\% in the surgically treated patients (median follow-up 5 months). Mean chromogranin A levels decreased by 56.2\% in patients undergoing surgery. CONCLUSIONS: Gastric antrectomy is the most efficacious treatment for Type 1 gastric carcinoid, leading to a significant reduction in serum gastrin levels and regression of carcinoid tumors. (c) 2006 Wiley-Liss, Inc. This article was published in J Surg Oncol and referenced in Journal of Gastrointestinal & Digestive System

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