alexa Pre-treatment, baseline, and outcome differences between early-onset and adult-onset psychosis in an epidemiological cohort of 636 first-episode patients.


Journal of Mental Disorders and Treatment

Author(s): Schimmelmann BG, Conus P, Cotton S, McGorry PD, Lambert M

Abstract Share this page

Abstract OBJECTIVES: To assess pre-treatment, baseline, and outcome differences of patients with early- (onsetor=age 18) psychosis in an epidemiological cohort of first-episode patients. METHODS: The Early Psychosis Prevention and Intervention Centre (EPPIC) in Australia admitted 786 FEP patients from January 1998 to December 2000. Data were collected from patients' files using a standardized questionnaire. Seven hundred four files were available, 61 of which were excluded owing to non-psychotic diagnoses or a psychotic disorder due to a general medical condition and 7 owing to missing data on age at onset. 636 patients were analyzed. RESULTS: The mean age at onset was 21.3 years (SD 3.6); the prevalence of early-onset psychosis was 18.6\% (onset range 8.2-17.9). Patients with early-onset were likely to have a slightly, but significantly worse premorbid functioning and a significantly longer duration of untreated psychosis (Median 26.3 weeks) compared to patients with adult-onset (Median 8.7 weeks; p<.001). After controlling for relevant confounders, no significant outcome differences including CGI-S, GAF, remission of positive symptoms, or employment status were detected between early- and adult-onset psychoses. CONCLUSIONS: Patients with early-onset psychosis may require a different approach to early detection. Outcome differences between early- and adult-onset were minor, but need to be replicated in future (long-term) prospective epidemiological studies in other services. This article was published in Schizophr Res and referenced in Journal of Mental Disorders and Treatment

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version