alexa Prevalence and characteristics of HPV infection in oropharyngeal cancer
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): De Stefani A, Boffano P, Averono G, Ramella A, Pia F

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BACKGROUND:

The purpose of this prospective study was to analyze the human papillomavirus (HPV) infection status and its impact on the outcome in a consecutive series of patients affected by oropharyngeal cancer.

METHODS:

The specimens of consecutive subjects surgically treated for oropharyngeal squamous cell carcinoma were obtained. Samples were collected by broom-type cell sampling devices and they underwent the Roche Linear Array HPV Genotyping Test to identify the presence of HPV types.

RESULTS:

In all, 52 patients were enrolled. The presence of HPV was detected in 13 samples, with HPV type 16 as the most frequently encountered type. Statistically significant associations were found between HPV-positive patients and a higher tumor grading (P < 0.05), and between HPV-positive patients and a higher number of negative prognostic factors (P < 0.05).

CONCLUSIONS:

A subset of oropharyngeal squamous cell carcinomas with a higher tumor grading is strongly linked to HPV16 infection.

This article was published in J Craniofac Surg. and referenced in Journal of Carcinogenesis & Mutagenesis

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