alexa Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit.


Clinical Depression

Author(s): Kalil AC, Florescu DF

Abstract Share this page

Abstract INTRODUCTION: Cytomegalovirus is the most common viral opportunistic infection in immunocompromised patients. However, recent studies have demonstrated active cytomegalovirus infection in nonimmunosuppressed intensive care unit patients. OBJECTIVE: To define the frequency and mortality rate associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. METHODS: A systematic review up to October 2008 was performed. Pooled results were analyzed by fixed- and random-effects models. Cochran Q and I2 were performed for heterogeneity. RESULTS: Thirteen studies (n = 1258) were selected. The overall rate of active cytomegalovirus infection was 17\% (95\% confidence interval [CI], 11\% to 24\%; p < .0001; I2 = 86\%). When the patients were screened for > or =5 intensive care unit days, the overall rate of infection increased to 21\% (95\% CI, 15\% to 29\%; p < .001). The infection rate for studies that used cytomegalovirus DNA/antigen for diagnosis was 20\% (95\% CI, 13\% to 31\%; p < .0001) and for studies that used culture was 12\% (95\% CI, 6\% to 22\%; p < .0001). The cytomegalovirus rate for patients with unknown serology was 7\% (95\% CI, 3\% to 14\%; p < .0001), whereas the rate for patients with positive serology was 31\% (95\% CI, 22\% to 42\%; p < .0001). The rate of infection was higher in patients with severe sepsis: 32\% (95\% CI, 22\% to 45\%; p < .0001). And in patients with high disease severity: 32\% (95\% CI, 23\% to 42\%; p < .0001). The overall mortality rate associated with active cytomegalovirus infection was 1.93 times (95\% CI, 1.29 to 2.88; p = .001) as high as that without cytomegalovirus infection. CONCLUSIONS: Active cytomegalovirus infection occurs frequently in nonimmunosuppressed patients in intensive care, especially in those with positive cytomegalovirus serology, intensive care unit stay > or =5 days, severe sepsis, and high disease severity, in whom the rate of cytomegalovirus infection is up to 36\%. Mortality rate is significantly doubled with cytomegalovirus, but a cause-effect relationship cannot be established yet. A large prospective cohort study on the patient population identified by our findings is needed to define who is at the highest risk for developing active cytomegalovirus infection and to determine its effects on mortality. This article was published in Crit Care Med and referenced in Clinical Depression

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version