alexa Prevalence and risk factors for resistant hypertension among hypertensive patients from a developing country.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacogenomics & Pharmacoproteomics

Author(s): Kumara WA, Perera T, Dissanayake M, Ranasinghe P, Constantine GR

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Abstract BACKGROUND: To study the prevalence and define deferential risk factors for 'Resistant' hypertension (RHT) in a hypertensive population of South Asian origin. METHODS: A descriptive cross-sectional study was carried out among hypertensive patients attending clinics at the Cardiology Unit, Colombo from July-October 2009. All the patients with hypertension who provided informed written consent were recruited to the study (n = 277). A pre-tested interviewer-administered questionnaire was used for data collection. A binary logistic-regression analysis was performed in all patients with 'presence of RHT' as the dichotomous dependent variable and other independent co-variants. RESULTS: Mean age was 61 ± 10.3 years and 50.2\% were males. The mean of average systolic and diastolic blood pressures (BP) were 133.04 ± 12.91 mmHg and 81.07 ± 6.41 mmHg respectively. Uncontrolled BP was present in 41.1\% (n = 114) of patients, of which RHT was present in 19.1\% (n = 53). Uncontrolled BP were due to 'therapeutic inertia' in 27.8\% of the study population. Those with diabetes mellitus, obesity (BMI > 27.5 kg/m2) and those who were older than 55 years were significantly higher in the RHT group than in the non-RHT group. In the binary logistic regression analysis older age (OR:1.36), longer duration of hypertension (OR:1.76), presence of diabetes mellitus (OR:1.67) and being obese (OR:1.84) were significantly associated with RHT. CONCLUSION: A significant proportion of the hypertensive patients were having uncontrolled hypertension. Nearly 1/5th of the population was suffering from RHT, which was significantly associated with the presence of obesity and diabetes mellitus. Therapeutic inertia seems to contribute significantly towards the presence of uncontrolled BP.
This article was published in BMC Res Notes and referenced in Journal of Pharmacogenomics & Pharmacoproteomics

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