Author(s): SantiagoMunoz P, Roberts S, Sheffield J, McElwee B, Wendel GD Jr, SantiagoMunoz P, Roberts S, Sheffield J, McElwee B, Wendel GD Jr
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Abstract OBJECTIVE: The purpose of this study was to evaluate the prevalence of hepatitis B and hepatitis C virus co-infection among pregnant women who are infected by human immunodeficiency virus and who attend an obstetric complications prenatal clinic. STUDY DESIGN: A de-identified research obstetric human immunodeficiency virus database was reviewed regarding patient demographic characteristics, risk factors for infection, history of sexually transmitted diseases, and initial CD4 count. RESULTS: Four hundred fifty-five women who are infected with human immunodeficiency virus with 572 pregnancies were delivered over 11 years. The overall prevalence of human immunodeficiency virus and hepatitis B or C virus co-infection in our population was 6.3\%. More specifically, 1.5\% was co-infected with hepatitis B virus, and 4.9\% was co-infected with hepatitis C virus. Patients with hepatitis virus were more likely to use intravenous drugs (52\% vs 18\%; P < .01) and alcohol (38\% vs 5\%; P < .01). Co-infected patients were older (28 vs 25.6 years; P=.04), but there were no racial differences. Median baseline CD4 counts in hepatitis B virus co-infected patients were significantly lower (310 cells/mm3) than those in either hepatitis C virus co-infected patients (453 cells/mm3) or patients who were not co-infected with human immunodeficiency virus (414 cells/mm3). CONCLUSION: One of 16 pregnant women who were infected with human immunodeficiency virus was co-infected with hepatitis B or hepatitis C virus. Hepatitis B co-infections appear to be associated with more compromised immune status in our cohort.
This article was published in Am J Obstet Gynecol
and referenced in Journal of AIDS & Clinical Research