Author(s): Kim DH, Sabour S, Sagar UN, Adams S, Whellan DJ
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Abstract This cross-sectional study examined the burden of cardiovascular diseases (CVDs) using serum 25-hydroxyvitamin D (25[OH]D) and prevalence of hypovitaminosis D in adults with CVDs using data from NHANES 2001 to 2004. Serum 25(OH)D levels were divided into 3 categories (> or =30, 20 to 29, and <20 ng/ml), and hypovitaminosis D was defined as vitamin D <30 ng/ml. Of 8,351 adults who had 25(OH)D measured, mean 25(OH)D was 24.3 ng/ml, and the prevalence of hypovitaminosis D was 74\%. The burden of CVDs increased with lower 25(OH)D categories, with 5.3\%, 6.7\%, and 7.3\% coronary heart disease; 1.5\%, 2.4\%, and 3.2\% heart failure; 2.5\%, 2.0\%, and 3.2\% stroke; and 3.6\%, 5.0\%, and 7.7\% peripheral arterial disease. Across all CVDs, hypovitaminosis D was more common in blacks than Hispanics or whites. Compared with persons at low risk for CVDs (68\%), it was more prevalent in those at high risk (75\%; odds ratio [OR] 1.32, 95\% confidence interval [CI] 1.05 to 1.67), with coronary heart disease (77\%; OR 1.48, 95\% CI 1.14 to 1.91), and both coronary heart disease and heart failure (89\%; OR 3.52, 95\% CI 1.58 to 7.84) after controlling for age, race, and gender. In conclusion, hypovitaminosis D was highly prevalent in US adults with CVDs, particularly those with both coronary heart disease and heart failure.
This article was published in Am J Cardiol
and referenced in Journal of Nutrition & Food Sciences