Author(s): Lindstrm I, KadduMulindwa DH, Kironde F, Lindh J
Abstract Share this page
Abstract Untreated Toxoplasma gondii-infections are often fatal in AIDS-patients. Many African countries struck hard by HIV/AIDS exhibit a high seroprevalence of T. gondii, but the rate of reactivated parasites among African HIV-patients has never previously been determined. In this study, IgG-agglutination and PCR was used to analyse blood samples from 130 HIV-positive patients in Uganda. Anti-T. gondii antibodies were detected in 54\% of the patients while 23\% had parasites in the peripheral blood, which indicates active infection. Genotyping of the SAG2-locus revealed the type II allele for most disease-causing strains (60\%), but all three SAG2-types was represented in our study population. Furthermore, one sample appeared to harbour a recombinant strain, with SAG2 type II but the type I-allele at the BTUB-gene. This study emphasizes the high prevalence of toxoplasmosis among Ugandan HIV-patients and also suggests that recombinant or atypical strains may be present in this part of the world.
This article was published in Acta Trop
and referenced in Journal of Antivirals & Antiretrovirals