Author(s): Koenig KF, Ribi C, Radosavac M, Zulewski H, Trendelenburg M Swiss
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Abstract OBJECTIVES: Systemic lupus erythematosus (SLE) is associated with considerable cardiovascular morbidity that has not yet been directly compared with other diseases with known cardiovascular risk. METHODS: Two hundred and forty-one patients of the multicentre Swiss SLE cohort study (SSCS) were cross-sectionally assessed for coronary heart disease (CHD), cerebrovascular disease (CVD) and peripheral artery disease (PAD). SLE patients were compared with a cohort of 193 patients with type-1 diabetes mellitus being followed at the University Hospital Basel. A subgroup analysis of 50 age- and sex-matched patients from the University Hospital Basel was performed. RESULTS: Of patients within the SSCS 13.3\% had one or more vascular events: 8.3\% CHD, 5\% CVD and 1.2\% PAD. In type-1 diabetes mellitus patients, 15\% had vascular events: 9.3\% CHD, 3.1\% CVD and 5.6\% PAD. In the matched subgroup, 26\% of SLE patients had vascular events (14\% CHD) compared with 12\% in type-1 DM patients (2\% CHD). Cardiovascular risk factors were similar in both groups. Vascular events in SLE patients were associated with age, longer disease duration, dyslipidaemia, and hypertension. CONCLUSION: Cardiovascular morbidity in SLE is at least as frequent as in age- and sex-matched type-1 diabetes mellitus patients. Therefore, aggressive screening and management of cardiovascular risk factors should be performed. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
This article was published in Lupus
and referenced in Journal of Antivirals & Antiretrovirals