alexa Primary leiomyosarcoma of the kidney: a clinicopathologic study of 27 cases.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Miller JS, Zhou M, Brimo F, Guo CC, Epstein JI

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Abstract Primary leiomyosarcoma of the kidney is a rare entity that has not been well characterized. We retrieved 27 cases of primary renal leiomyosarcomas diagnosed at 3 institutions between 1986 and 2009. Mean patient age at diagnosis was 58.5 years (range 22 to 85), and 59\% were female. Mean tumor size was 13.4 cm (range 4 to 26), and 59\% of the tumors were identified in the right kidney. Detailed histologic examination was possible for 24 of the cases. Average mitotic count per 10 high-power fields was 11.1 (range 0 to 50), and the average extent of necrosis was 21\% (range 0 to 60). Cellular pleomorphism was classified as either focal (n = 13) or extensive (n = 11) and graded as mild (n = 3), moderate (n = 7) or severe (n = 14). Tumors were either grade 2 (n = 12) or grade 3 (n = 12) using the French Federation of Cancer Centers System. Direct extension beyond the kidney capsule was identified in 55\% of the cases, and lymphovascular invasion was identified in 26\%. Clinical follow-up information was available for 20 of the cases, and patients were followed for an average of 2.8 years (range 0.25 to 9). Distant metastases were identified in 90\% of the patients, and 75\% eventually died from their tumor's burden. In conclusion, primary renal leiomyosarcomas have a grim prognosis regardless of the underlying histology. This article was published in Am J Surg Pathol and referenced in Journal of Cancer Science & Therapy

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