Author(s): Brundin P, Melki R, Kopito R, Brundin P, Melki R, Kopito R
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Abstract Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.
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This article was published in Nat Rev Mol Cell Biol
and referenced in Journal of Alzheimers Disease & Parkinsonism