alexa Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain.


Biochemistry & Analytical Biochemistry

Author(s): Omura S, Ikeda H, Malpartida F, Kieser HM, Hopwood DA

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Abstract Hybrid antibiotics mederrhodins A and B were produced by a recombinant strain consisting of the medermycin-producing Streptomyces sp. strain AM7161 containing part of the gene clusters for actinorhodin biosynthesis of Streptomyces coelicolor A3(2). Mederrhodin A has a hydroxyl group at the C-6 position of the medermycin molecule, and mederrhodin B is dihydromederrhodin A. The antimicrobial activity of mederrhodin A resembled that of medermycin. Mederrhodin B was almost devoid of antimicrobial activity.
This article was published in Antimicrob Agents Chemother and referenced in Biochemistry & Analytical Biochemistry

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