alexa Profibrillatory effects of intracoronary thrombus in acute regional ischemia of the in situ porcine heart.


Journal of General Practice

Author(s): Coronel R, WilmsSchopman FJ, Janse MJ

Abstract Share this page

Abstract BACKGROUND: An intracoronary thrombus during regional ischemia is related to life-threatening arrhythmias. The electrophysiological consequences of a thrombus are unknown. METHODS AND RESULTS: In open chest pigs, regional ischemia was induced by intracoronary injection of a thrombus (protocol 1). In protocol 2, coronary ligation was followed by injection of heparinized blood. Three consecutive episodes of ischemia (10 minutes) and reperfusion (20 minutes) were studied in protocols 3 and 4 (ligation). During the former, an intracoronary thrombus started the third period of ischemia. Multiple (78) local electrograms were recorded simultaneously, and activation patterns were determined. In a first period of ischemia, ventricular fibrillation (during the first 10 minutes) occurred more often after intracoronary thrombosis than during the other protocols (4/7 versus 2/19, P<.05) despite similar size of the ischemic tissue. The incidence of delayed arrhythmias (between 15 and 30 minutes) was not different. Epicardial activation delay was larger 2 to 4 minutes after intracoronary thrombosis compared with ligation. ST elevation was larger with than without a thrombus (2 minutes of ischemia, 12.9+/-4.1 versus 8.2+/-3.0 mV; +/-SD, P<.05). In protocols 3 and 4 the second period and third period of ischemia were similar irrespective of the presence of an intracoronary thrombus. CONCLUSIONS: More conduction slowing underlies the profibrillatory effect of an intracoronary thrombus relative to coronary ligation. After preconditioning with ischemia, the profibrillatory effects are no longer detectable.
This article was published in Circulation and referenced in Journal of General Practice

Relevant Expert PPTs

Relevant Speaker PPTs

  • Trent Jackman
    Exploratory comparison of credentialed clinical instructors’ and non-credentialed clinical instructors’ report of frequency and importance of professional behaviors in clinical education
    PPT Version | PDF Version
  • Elucir Gir
    Nasal colonization by microorganisms in nursing professionals in units specializing in HIV/AIDS
    PPT Version | PDF Version
  • Nina Turnage
    Researchers, medical doctors, academic scientists and cosmetologists. The advancement of cosmetology and trichology through stem and establishing professional relationships
    PPT Version | PDF Version

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version