Author(s): Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA, , Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA,
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Abstract The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 180 seropositive men studied for more than 10 years. The risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects, including those with normal numbers of CD4+ T cells, was directly related to plasma viral load at study entry. Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4+ T cells.
This article was published in Science
and referenced in Journal of AIDS & Clinical Research