alexa Prognosis of adult onset polycystic kidney disease re-evaluated.
Biochemistry

Biochemistry

Biochemistry & Physiology: Open Access

Author(s): Churchill DN, Bear JC, Morgan J, Payne RH, McManamon PJ,

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Abstract To appraise the prognosis of adult onset polycystic kidney disease (APKD), an inception cohort containing 140 subjects from 17 kindreds was assembled. Multiple renal cysts, demonstrable by ultrasonography, or clinical APKD, or both were present in 100 subjects. APKD was predicted in 32 subjects unavailable for ultrasonography and could not be excluded in eight deceased subjects. All had been at risk for endstage renal disease (ESRD) since birth. The probability of either developing ESRD, requiring dialysis or transplantation, or dying was estimated using a time-to-event analysis. The earliest age at which ESRD occurred was 36 years. For those with APKD, the probability of being alive and not having ESRD was 77\% by age 50, 57\% by age 58, and 52\% by age 73 years. Excluding those predicted to have APKD changes these probabilities to 75, 53, and 47\%, respectively. The serum creatinine values were less than 1.5 mg/dl for most subjects who had not developed ESRD. The prognosis for subjects with APKD is much better than most reports suggest and can be estimated from the time-to-event data presented.
This article was published in Kidney Int and referenced in Biochemistry & Physiology: Open Access

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