Author(s): Aziz M, Qadir A, Aziz M, Faizullah
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Abstract OBJECTIVE: To discuss the effect of duration of illness before perforation and time interval between perforation and surgery on the prognosis of typhoid perforation. DESIGN: Comparative study. PLACE AND DURATION OF STUDY: Nishtar Hospital, Multan from September 2002 to September 2004. PATIENTS AND METHODS: Seventy-two patients of typhoid perforation were included in this study. The patients were divided into three groups A, B and C according to duration of illness before perforation. In these groups, typhoid perforation occurred during 1st, 2nd and 3rd week respectively. Further patients were divided into group D, E and F according to time interval between perforation and surgery. In these groups surgery was carried out within 24 hours, 24-48 hours and after 48 hours respectively. RESULTS: Fifty-six patients were males and 16 were females. In groups A, B and C, mortality rate was 6.6\%, 13.3\% and 25\%, while morbidity rate was 33.3\%, 55.5\% and 75\% respectively. There were 12, 42 and 18 patients in Group D, E and F with mortality rate of 8.33\%, 11.9\% and 22.2\% respectively. Group D had 41.6\% morbidity rate while group E and F had 71.42\% and 77.7\% respectively. CONCLUSION: In this study, early perforation during the typhoid fever and short perforation-operation interval were good prognostic signs. So best results can be achieved by early patient's presentation and early operation.
This article was published in J Coll Physicians Surg Pak
and referenced in Journal of Addiction Research & Therapy