alexa Prognostic role of the let-7 family in various carcinomas: A meta-analysis update.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Genetic Syndromes & Gene Therapy

Author(s): Zhang CL, Li Z, Liu YP, Wu Y, Qu XJ

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Abstract PURPOSE: The role of let-7 family members in cancer prognosis has been the subject of increasing interest; however, the correlation between let-7 expression and cancer prognosis remains unknown. The goal of this study was to investigate the prognostic role of let-7 expression by performing a meta-analysis update of 31 studies. METHODS: All relevant studies were searched on PubMed and Web of Science. The pooled hazard ratios (HRs) and 95\% confidence intervals (CIs) were calculated, and subgroup analysis was performed for overall survival (OS) and disease-free survival (DFS) to evaluate the relationship between high let-7 expression and cancer prognosis. Heterogeneity and publication bias were also investigated. RESULTS: We discovered that high let-7 expression can predict a better OS (pooled HR=0.69, 95\% CI 0.60-0.80, transformed from lnHR and its 95\% CI) and DFS (pooled HR=0.72, 95\% CI 0.54-0.96, transformed from lnHR and its 95\% CI) in various carcinomas, especially in digestive cancer. Subgroup analysis showed that high let-7 expression was significantly associated with a better DFS in Asians (pooled HR=0.50, 95\% CI 0.39-0.64, transformed from lnHR and its 95\% CI). CONCLUSIONS: This meta-analysis showed that high let-7 expression is a prognostic factor for better OS and DFS in cancer patients, with particularly better DFS among the Asian populations. These results suggest that clinicians should treat patients with low let-7 expression more carefully. Future studies in large-scale populations among different ethnicities and regions are needed to definitively determine if let-7 expression can be used as a predicative biomarker for clinical assessment.
This article was published in J BUON and referenced in Journal of Genetic Syndromes & Gene Therapy

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