alexa Proinflammation of aging central arteries: a mini-review.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacognosy & Natural Products

Author(s): Wang M, Monticone RE, Lakatta EG

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Abstract Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional alterations are consequences of adverse molecular and cellular events, e.g. an increase in local angiotensin II signaling that induces an inflammatory phenotypic shift of endothelial and smooth muscle cells. Thus, interventions to restrict proinflammatory signaling are a rational approach to delay or prevent age-associated adverse arterial remodeling. © 2014 S. Karger AG, Basel.
This article was published in Gerontology and referenced in Journal of Pharmacognosy & Natural Products

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