alexa Prolactin level is significantly elevated in lesional skin of patients with psoriasis.


Medicinal chemistry

Author(s): ElKhateeb EA, ZuelFakkar NM, Eid SM, AbdulWahab SE

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Abstract BACKGROUND: Accumulating data point to a potential role of prolactin in the pathogenesis of psoriasis. METHODS: We initiated a study including psoriasis patients (n = 15) and healthy volunteers (n = 15) as controls. Psoriasis area and severity index (PASI) score was evaluated, and prolactin levels in serum and blister fluid were assessed by enzyme-linked immunosorbent assay (ELISA). RESULTS: Prolactin levels were significantly (P < 0.01) elevated in blister fluid of psoriatic lesional skin. Correlations between PASI score and different serum prolactin levels in lesional and non-lesional skin were insignificant. Significant positive correlations of prolactin level were observed between lesional and non-lesional skin in psoriasis (P < 0.05) and between serum and clinically normal skin in both psoriasis and control subjects (P < 0.05). CONCLUSIONS: Locally produced prolactin may be involved in the pathogenesis of psoriatic lesions. © 2011 The International Society of Dermatology. This article was published in Int J Dermatol and referenced in Medicinal chemistry

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