alexa Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Piacibello W, Gammaitoni L, Pignochino Y

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Abstract The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.
This article was published in Folia Histochem Cytobiol and referenced in Journal of Stem Cell Research & Therapy

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