Author(s): Menaa F, Badole SL, Menaa B, Menaa A
Melanoma is a highly aggressive, therapy-resistant skin cancer, representing an increasing health problem due to its complex etiology, heterogeneity, and modest results obtained with the current treatment options. Development of targeted bioactive phytochemicals as therapeutics might provide better choices for melanoma tumor regression and enhancement in patient’s survival. Therefore, the constant search for alternative drugs that are effective, specific, and nontoxic in the treatment of melanoma is required and encouraged. Very few, but emerging studies, mainly published during the last decade, purposed that some plant extracts, contain effective and low-adverse effects anti-melanoma drug. In this review, based on the relevant literature and relatively recent in vivo studies using melanoma-bearing animal models, we report five most plant extracts which are promising in the prevention and/or the treatment of melanoma.