alexa Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): da Fonseca EB, Bittar RE, Carvalho MH, Zugaib M

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Abstract OBJECTIVE: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN: A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administered daily by vaginal suppository and all patients underwent uterine contraction monitoring with an external tocodynamometer once a week for 60 minutes, between 24 and 34 weeks of gestation. Progesterone (n = 72) and placebo (n = 70) groups were compared for epidemiologic characteristics, uterine contraction frequency, and incidence of preterm birth. Data were compared by chi(2) analysis and Fisher exact test. RESULTS: The preterm birth rate was 21.1\% (30/142). Differences in uterine activity were found between the progesterone and placebo groups (23.6\% vs 54.3\%, respectively; P <.05) and in preterm birth between progesterone and placebo (13.8\% vs 28.5\%, respectively; P <.05). More women were delivered before 34 weeks in the placebo group (18.5\%) than in the progesterone group (2.7\%) (P <.05). CONCLUSION: Prophylactic vaginal progesterone reduced the frequency of uterine contractions and the rate of preterm delivery in women at high risk for prematurity.
This article was published in Am J Obstet Gynecol and referenced in Biochemistry & Analytical Biochemistry

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