alexa Prostaglandin release from lumbar disc and facet joint tissue.
Medicine

Medicine

General Medicine: Open Access

Author(s): Willburger RE, Wittenberg RH

Abstract Share this page

Abstract OBJECTIVES: The authors measured prostaglandin (PG) and leukotriene (LT) release from human disc and lumbar facet joint tissues. SUMMARY OF BACKGROUND DATA: High levels of phospholipase A2 (PLA2) have been measured in the human disc. PLA2 releases fatty acids from lipid membranes. These can be converted to PG and LT, which are potent inflammatory mediators and supposed to be involved in lumbar diseases. METHODS: The tissues were obtained during surgery and incubated in Tyrode's solution. PG and LT release was measured radioimmunologically from the supernatant. RESULTS: Disc (4 ng/g wet weight), cartilage (21 ng/g wet weight), and bone (14 ng/g wet weight) released PGs but no LTs. CONCLUSION: Because PG release from sequestrated disc is rather low, the inflammatory effect might be more because of immunologic reactions.
This article was published in Spine (Phila Pa 1976) and referenced in General Medicine: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords