alexa Prostate-specific antigen and history of its discovery.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Zaviacic M

Abstract Share this page

Abstract In contradistinction to prostatic acid phosphatase (PAcP), prostate-specific antigen (PSA) is currently the most reliable and most frequently used marker for identification of normal and pathologically altered prostatic tissues both in the male and female. In clinical practice, it has become an appreciated serum marker in the assessment and management of prostate carcinoma in the male, although it is far from being a perfect "tumor" marker. Our knowledge on female PSA is expected to be broadened by the introduction of novel highly sensitive serological methods (IMMULITE--immunochemiluminiscent third-generation PSA assay and others), which in some females have already demonstrated surprisingly high values. Biochemically, PSA in seminal fluid in its free form has a molecular weight of about 30,000 daltons, while in serum, where it occurs in the complex form with alpha1-chymotrypsin, its molecular weight is approximately 100,000 daltons being comparable to that of PAcP. On immunohistochemical examination, PSA is expressed in the highly specialized apically-superficial layer of male and female secretory (luminal) cells of the prostatic glands, as well as at other sites of the urogenital tract, frequently coinciding with glucosamine glucans, glycoproteins and numerous enzyme proteins. With regard to the increasing interest in PSA evidenced in urology, gynecological urology, in the orthology and pathology of male and female prostates, the interest in the history of discovery of this exceptional prostatic marker appears to be justified. PSA was discovered by Richard Ablin and co-workers in the USA, who published their pioneer work in the Journal of Reproduction and Fertility and in the Journal of Immunology as early as in 1970. Thus their results had been available nine years before the publication of Wang et al. appeared in Investigative Urology (1979), on the basis of which the latter are frequently incorrectly considered and cited as the authors of PSA discovery. (Ref. 46.)
This article was published in Bratisl Lek Listy and referenced in Journal of Molecular Biomarkers & Diagnosis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 9th International Conference and Expo on Molecular & Cancer Biomarkers
    August 23-24, 2017 Birmingham, UK
  • 2nd International Conference on Medical Imaging and Diagnosis
    London, UK
  • 22nd International Conference on Cancer Drugs and Therapeutics
    Paris, France
  • International Conference on Oncology Nursing and Cancer Care
    Singapore City, Singapore
  • World Summit on Cell Signalling and Cancer Therapy
    Toronto, Canada
  • International Conference on Radiology and Imaging
    New York, USA

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords