Author(s): Sampson SL, Dascher CC, Sambandamurthy VK, Russell RG, Jacobs WR Jr,
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Abstract We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The deltaleuD deltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.
This article was published in Infect Immun
and referenced in Journal of Bioprocessing & Biotechniques